The World Health Organization released new statistics on the rate of preterm birth around the world. The bottom line is preterm birth rates are still high. About 15 million babies are born preterm every year. In 2013 almost 1 million babies died from complications related to preterm birth. Increased knowledge on the cause of preterm and better solutions to prevent it from happening are much needed.
Publication Alert: Collagen Crosslinks and Tensile Structural Properties in Mouse Cervix Throughout Gestation
Our paper titled, “Quantitative Evaluation of Collagen Crosslinks and Corresponding Tensile Mechanical Properties in Mouse Cervical Tissue during Normal Pregnancy” has been published in the open source journal, PLOS ONE. Here, we report our findings on both mature and immature collagen crosslink density throughout mouse gestation and how it correlates to tensile structural properties.
Thank you to our collaborators and co-authors for your contributions!
The Myers lab is featured in this Summer’s edition of Connections (pages 7-8) – a Newsletter from the Columbia University Medical Center Department of Obstetrics and Gynecology. The article details our collaborative relationship with clinicians and scientists to unravel the causes of preterm birth. Here, we discuss how we use our finite elements models of pregnancy to understand how the cervix acts as a mechanical barrier to protect the fetus.
The Myers Lab will be presenting 2 podium and 1 poster presentation at this year’s World Congress of Biomechanics in Boston. These presentations will be a part of the Reproductive Biomechanics and FEBio Symposia.
Reproductive Biomechanics Symposium:
1. The Constitutive Modeling of Human Cervical Tissue, presented by Kristin M.Myers
2. Cervical Tissue Remodeling and Collagen Crosslinks in Infection and Non-Infection Based Preterm Birth Mouse Models, presented by Kyoko Yoshida
Coauthors: Joy Vink, MD, Ronald Wapner, MD, Mala Mahendroo, PhD, Michael Fernandez, Wang (Frank) Yao, Noelia Zork, MD, Serge Cremers, PhD Honfeng Jiang, PhD, & David Paik, MD
The Myers lab had the pleasure to join fellow mechanics colleagues and other former students to honor Alan Wineman in his 50th year of teaching at the University of Michigan at this year’s USNCTAM meeting at MSU. Our work in trying to understand and model the complex collagen remodeling behavior of cervical tissue during pregnancy is directly inspired by Prof. Wineman’s work in scission and crossliking of rubbers. Kudos, Alan, to an amazing career and inspiring so many students!
A recent Wall Street Journal Article (published: Tuesday, July 16th, 2013) discusses the possible detrimental effects of long-term bed rest during pregnancy. Often bed rest is prescribed to prevent preterm birth due to premature cervical dilation (aka cervical insufficiency). However, since not much is known about the mechanics of cervical remodeling and dilation, the efficacy of bed rest to prevent preterm birth is unknown.