We proposed a new material model that captures the tension–compression asymmetric material responses and the remodeling characteristics of both human and mouse cervical tissue. We present tension-compression mechanical data, nonpregnant vs pregnant comparisons, a full 3-D statistical mechanics model, links to raw data, and material model implementation in FEBio.

This article is written by Lei Shi.

Article – Acta Biomaterialia
Three-dimensional anisotropic hyperelastic constitutive model describing the mechanical response of human and mouse cervix

The members of the Myers lab have been on the move this year, attending conferences and working with collaborators. We’re so happy to see everyone in-person!

Congratulations to Myers Lab member Shuyang Fang for placing first in the SB3C 2021 ASME-BED Student Paper Competition (PhD level, Soft Tissue Biomechanics section). Great job Shuyang!

What is the mechanical role of small leucine-rich proteoglycans (SLRPs) in the mouse cervix? In collaboration with the Mahendroo lab at the University of Texas Southwestern Medical Center, we use mechanical testing and computational modeling to reveal decorin and biglycan’s impact on time-dependent and equilibrium properties of the nonpregnant and pregnant cervix.

This article is written by Nicole Lee in collaboration with Mala Mahendroo

Article – Journal for Biomechanical Engineering
Mechanical Response of Mouse Cervices Lacking Decorin and Biglycan During Pregnancy

What is the role of small leucine-rich proteoglycans (SLRPs) in cervical remodeling during pregnancy? In collaboration with the Mahendroo lab at the University of Texas Southwestern Medical Center, the combination of imaging, immunohistochemistry, collagen crosslink analysis, and mechanical testing reveals an important regulatory role of SLRPs in the uterine cervix.

This article is written by Mariano Colon-Caraballo (from collaborator Mala Mahendroo’s lab), co-authored by Nicole Lee.

Article – Matrix Biology
Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy

We loved having Jada Hinds, a 2021 SURE Fellow from Duke University, as an undergraduate researcher in our lab over the summer! You can watch her present her work on studying the effects of maternal anatomy parameters on cervical loading at the Columbia SURE website.

The Myers Lab congratulates Lei Shi on his well-deserved doctoral degree from Columbia University! Lei’s work mechanically testing and modeling the human cervix not only characterizes the equilibrium response of human cervical tissue, but also pioneers capturing its time-dependent mechanical response.

Congratulations to Myers Lab members Nicole Lee and Arielle Feder for placing in the SB3C 2021 ASME-BED Student Paper Competition! Nicole Lee tied for first place at the PhD level in the Soft Tissue Biomechanics section, and Arielle Feder got runner-up at the BS level in the Soft Tissues section. We couldn’t be more proud!

How do mechanical properties of the human uterus change throughout pregnancy, and how do they differ across uterine anatomical locations? We combine video extensometry, mechanical testing and computational modeling to explore in our recently published manuscript.

The article is written by Shuyang Fang in collaboration with Christine Hendon.

Article – Bioengineering for Women’s Health
Anisotropic Mechanical Properties of the Human Uterus Measured by Spherical Indentation

Raw data – Academic Commons
Spherical Indentation Data:
https://academiccommons.columbia.edu/doi/10.7916/d8-22r0-x041

Our new manuscript reports measurements from 2D ultrasound of uterine and cervical growth during pregnancy and a design table driven method to build patient-specific models.

The article is authored by Erin Louwagie in collaboration with Helen Feltovich at Intermountain Medicine/UoU and Timothy Hall at UW-Madison.

Article – PLOS ONE
Longitudinal ultrasonic dimensions and parametric solid models of the gravid uterus and cervix

Raw Data – Academic Commons
Ultrasound Measurements: https://academiccommons.columbia.edu/doi/10.7916/d8-g3bz-yj53
Solid Models: https://academiccommons.columbia.edu/doi/10.7916/d8-tchz-hs47
MRI Validation Models: https://academiccommons.columbia.edu/doi/10.7916/d8-gxv7-2z02