The Myers lab is featured in this Summer’s edition of Connections (pages 7-8) – a Newsletter from the Columbia University Medical Center Department of Obstetrics and Gynecology. The article details our collaborative relationship with clinicians and scientists to unravel the causes of preterm birth. Here, we discuss how we use our finite elements models of pregnancy to understand how the cervix acts as a mechanical barrier to protect the fetus.
Author Archives: kristinmyerscolumbia
The Myers Lab will be presenting 2 podium and 1 poster presentation at this year’s World Congress of Biomechanics in Boston. These presentations will be a part of the Reproductive Biomechanics and FEBio Symposia.
Reproductive Biomechanics Symposium:
1. The Constitutive Modeling of Human Cervical Tissue, presented by Kristin M.Myers
2. Cervical Tissue Remodeling and Collagen Crosslinks in Infection and Non-Infection Based Preterm Birth Mouse Models, presented by Kyoko Yoshida
Coauthors: Joy Vink, MD, Ronald Wapner, MD, Mala Mahendroo, PhD, Michael Fernandez, Wang (Frank) Yao, Noelia Zork, MD, Serge Cremers, PhD Honfeng Jiang, PhD, & David Paik, MD
The Myers lab had the pleasure to join fellow mechanics colleagues and other former students to honor Alan Wineman in his 50th year of teaching at the University of Michigan at this year’s USNCTAM meeting at MSU. Our work in trying to understand and model the complex collagen remodeling behavior of cervical tissue during pregnancy is directly inspired by Prof. Wineman’s work in scission and crossliking of rubbers. Kudos, Alan, to an amazing career and inspiring so many students!
A recent Wall Street Journal Article (published: Tuesday, July 16th, 2013) discusses the possible detrimental effects of long-term bed rest during pregnancy. Often bed rest is prescribed to prevent preterm birth due to premature cervical dilation (aka cervical insufficiency). However, since not much is known about the mechanics of cervical remodeling and dilation, the efficacy of bed rest to prevent preterm birth is unknown.
Our paper entitled “Interstitial growth and remodeling of biological tissues: Tissue composition as state variables” reviews the latest literature of cervical tissue remodeling during pregnancy and details a constitutive remodeling framework for evoling tissue properties based on the evolution of the tissue’s microstructure. This paper was co-authored by Gerard Ateshian and is available online.
The Myers lab presented two posters at this years SGI meeting in Orlando Florida. Both posters presented our investigation into the correlation between cervical mechanical strength and collagen crosslink density during cervical remodeling. Here, Kyoko explains her methodology to determine the swelling characteristics of the cervix during pregnancy.