Our paper titled, “Material properties of mouse cervical tissue in normal gestation” has been published in Acta Biomaterialia. This paper outlines our experimental and inverse finite element methods to calculate the material property changes of the mouse cervix in a normal pregnancy. Here, we found that cervical stiffness in a mouse decreases by 4 orders of magnitude within a 19-day mouse pregnancy. Our raw data from this study is also available at the Columbia University Library’s Academic Commons (http://dx.doi.org/10.7916/D8DN44QW)
Our preterm birth research is featured in the Fall/Winter 2015 Columbia Medicine Alumni Magazine along with all of our Columbia colleagues working towards understanding and reducing the burden of preterm birth.
The Myers lab has open graduate research positions in reproductive biomechanics. The job tasks include: the mechanical testing of collagenous tissues, investigating steroid hormone and extracellular matrix biochemistry, hyperelastic material constitutive modeling, analysis of the growth and remodeling of biologic tissues, and finite element modeling. Please contact firstname.lastname@example.org with your CV if interested.
Find our new finite element study of pregnancy on-line in Computer Methods in Biomechanics and Biomedical Engineering. This study calculates the mechanical loading on the cervix for two pregnant patients, using geometry derived from MRI scans and material parameters from our previous experiments.
Our clinical collaborator, Dr. Joy Vink has been selected as a 2015 Louis V. Gerstner Jr. Scholar. This program supports physician-scientists at the Columbia University Medical Center to conduct translational research designed to bring new treatments for patients.
Congratulations Dr. Vink!
Great news! Dr. Myers recently won the NSF CAREER award for her project, “Growth and Remodeling of the Uterine Cervix during Pregnancy”.
This award will help support our ongoing investigation of the underlying causes of preterm cervical remodeling. Specifically, this work will focus on determining the biochemical and mechanical property changes that occur under various hormonal cues during pregnancy.
Congratulations Dr. Myers!
The World Health Organization released new statistics on the rate of preterm birth around the world. The bottom line is preterm birth rates are still high. About 15 million babies are born preterm every year. In 2013 almost 1 million babies died from complications related to preterm birth. Increased knowledge on the cause of preterm and better solutions to prevent it from happening are much needed.
Publication Alert: Collagen Crosslinks and Tensile Structural Properties in Mouse Cervix Throughout Gestation
Our paper titled, “Quantitative Evaluation of Collagen Crosslinks and Corresponding Tensile Mechanical Properties in Mouse Cervical Tissue during Normal Pregnancy” has been published in the open source journal, PLOS ONE. Here, we report our findings on both mature and immature collagen crosslink density throughout mouse gestation and how it correlates to tensile structural properties.
Thank you to our collaborators and co-authors for your contributions!